Cannot apply security settings to resource HKEY_LOCAL_MACHINE\Software\....as it does not exist.

To resolve this issue, you must uninstall SharePoint 2010 FIS Enterprise from each server. Then, you must use a new FIS activation key to reinstall SharePoint 2010 FIS Enterprise on each server. To do this, follow these steps: 

1. Back up your current environment.
   
   This backup is to make sure that you have a safe copy of your data or for you to try this operation first on a set of test servers. We strongly recommend that you try this operation on test servers before you run it in production.
   
   For more information about how to back up your current environment, visit the following TechNet website:
   http://technet.microsoft.com/en-us/library/ee428315.aspx
2. Uninstall the current product from Control Panel, and then restart your computer.
   
   Note You do not have to uninstall any of the Microsoft SharePoint prerequisites.
3. Install by using the correct license type.
   
   Note You do not have to install any of the Microsoft SharePoint prerequisites.
   
   To install by using the correct license type, follow these steps:
   1. Log on to your account, and then retrieve a new SharePoint 2010 FIS Enterprise product key from the following website:
      https://www.microsoft.com/licensing/servicecenter/
      Note You have to obtain a new key. You do not have to download new installation media.
   2. For more information, see the following articles on the Microsoft TechNet website:
      http://technet.microsoft.com/en-us/library/cc262243.aspx (Single Server)
      http://technet.microsoft.com/en-us/library/ee805948.aspx (Multiple Server farms)
4. Verify that the correct license type is installed by using the SharePoint Management Console. To do this, follow these steps:
   1. Click Start, click All Programs, click Microsoft SharePoint 2010 Products, and then click SharePoint 2010 Management Console.
   2. In SharePoint 2010 Management Console, at the command prompt, type the following command, and then press ENTER:
      (Get-SPFarm).Products
   3. Make sure that one of the following GUIDs exists in the list:
      • B2C0B444-3914-4ACB-A0B8-7CF50A8F7AA0
      • D5595F62-449B-4061-B0B2-0CBAD410BB51
   4. Make sure that neither of the following GUIDs exists:
      • 1F230F82-E3BA-4053-9B6D-E8F061A933FC
      • F48AC5F3-0E33-44D8-A6A9-A629355F3F0C
5. Restore your data. For more information, see the instructions in the following Microsoft TechNet article:
   http://technet.microsoft.com/en-us/library/ee428303.aspx